{"effect":{"id":"fatigue","name":"Fatigue / Low energy","severity":"mild","description":"Feeling tired or having less energy than usual, especially in the first weeks.","clinicalRates":{"low":0.06,"medium":0.1,"high":0.14},"clinicalRatesNote":"A fixed published-literature dose-response reference (dated 2026-04-12), not derived from this corpus. The predictor uses it only as a fallback when the corpus has no eligible clinical rate points for this effect; otherwise the predictor uses the corpus's own weighted rate. The corpus's own pooled clinical estimate is published alongside — corpusClinical here, rateBase.clinical.pooledEstimate on the per-effect endpoint — and is null when the corpus has no eligible clinical rate points for the effect. Full per-source detail: rateBase.clinical via ?q=effect&id=<id>.","modifiers":{"femaleFactor":1.15,"ageFactor65plus":1.3,"giHistoryFactor":1,"diabetesFactor":1.1,"firstMonthFactor":1.8},"reportingFrequency":{"mentions":33,"distinctReports":185,"sharePct":17.8,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself — news-aggregator results are excluded, see platforms. Not an incidence rate; not comparable to clinicalRates."},"userReportedSeverity":"Commonly reported but often linked to eating significantly less. Your body is adjusting to lower caloric intake. Users say it improves after 2-3 weeks.","onsetDays":"5-10 days after starting","durationWeeks":"Usually improves within 2-3 weeks","managementTip":"Ensure you're eating enough protein and calories — fatigue often means you're eating too little. Light exercise actually helps more than resting.","sources":[{"name":"Real-world evidence review (PMC 2025)","type":"clinical","weight":0.3},{"name":"Reddit & Weegclub NL user discussions (2024-2026)","type":"user_report","weight":0.4},{"name":"British Journal of Pharmacology warning (2024)","type":"news","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11144546/","weight":0.3}]},"dataPointCount":74,"rateBase":{"note":"Only externally citable, non-duplicated rates support an estimate. Shares of spontaneous adverse-event reports (FAERS) are reported separately — they are not incidence.","clinical":{"statedRates":0,"distinctSources":0,"pooledEstimate":null,"sources":[],"excluded":{"self_referential":3,"spontaneous_report_share":6,"no_rate":1},"usesPublishedFallback":true},"community":{"statedRates":3,"distinctSources":1,"excluded":{"self_referential":3,"synthetic_source":1,"no_rate":57},"usesPublishedFallback":false},"spontaneousReportShares":[{"source":"FDA FAERS — semaglutide — FATIGUE","url":"https://api.fda.gov/drug/event.json?search=patient.drug.openfda.generic_name:\"semaglutide\"","shareOfReports":0.043,"reports":3563},{"source":"FDA FAERS — liraglutide — FATIGUE","url":"https://api.fda.gov/drug/event.json?search=patient.drug.openfda.generic_name:\"liraglutide\"","shareOfReports":0.038,"reports":1656},{"source":"FDA FAERS — tirzepatide — FATIGUE","url":"https://api.fda.gov/drug/event.json?search=patient.drug.openfda.generic_name:\"tirzepatide\"","shareOfReports":0.023,"reports":3179},{"source":"FDA FAERS — dulaglutide — FATIGUE","url":"https://api.fda.gov/drug/event.json?search=patient.drug.openfda.generic_name:\"dulaglutide\"","shareOfReports":0.024,"reports":2409},{"source":"FDA FAERS — exenatide — FATIGUE","url":"https://api.fda.gov/drug/event.json?search=patient.drug.openfda.generic_name:\"exenatide\"","shareOfReports":0.019,"reports":1759},{"source":"FDA FAERS — orforglipron — FATIGUE","url":"https://api.fda.gov/drug/event.json?search=patient.drug.openfda.generic_name:\"orforglipron\"","shareOfReports":0.061,"reports":70}]},"dataPointsBySource":{"clinical":4,"regulatory":6,"user_report":59,"news":5},"sampleDataPoints":[{"sourceName":"Real-world evidence review (PMC 2025)","sourceType":"clinical","sourceUrl":"https://magistra.health/nl/science#fatigue","extractedRate":0.06,"extractedSeverity":"mild","extractedSampleSize":200,"extractionConfidence":"high","scrapedAt":"2026-04-06T11:45:17.713Z"},{"sourceName":"Real-world evidence review (PMC 2025)","sourceType":"clinical","sourceUrl":"https://magistra.health/nl/science#fatigue","extractedRate":0.1,"extractedSeverity":"mild","extractedSampleSize":500,"extractionConfidence":"high","scrapedAt":"2026-04-06T11:45:17.713Z"},{"sourceName":"Real-world evidence review (PMC 2025)","sourceType":"clinical","sourceUrl":"https://magistra.health/nl/science#fatigue","extractedRate":0.14,"extractedSeverity":"mild","extractedSampleSize":300,"extractionConfidence":"high","scrapedAt":"2026-04-06T11:45:17.713Z"},{"sourceName":"Reddit & Weegclub NL user discussions (2024-2026)","sourceType":"user_report","sourceUrl":"https://magistra.health/nl/science#fatigue","extractedRate":0.06,"extractedSeverity":"mild","extractedSampleSize":200,"extractionConfidence":"high","scrapedAt":"2026-04-06T11:45:17.713Z"},{"sourceName":"Reddit & Weegclub NL user discussions (2024-2026)","sourceType":"user_report","sourceUrl":"https://magistra.health/nl/science#fatigue","extractedRate":0.1,"extractedSeverity":"mild","extractedSampleSize":500,"extractionConfidence":"high","scrapedAt":"2026-04-06T11:45:17.713Z"}],"lastUpdated":"2026-08-19"}