{"effect":{"id":"gallstones","name":"Gallstones (cholelithiasis)","severity":"severe","description":"Formation of gallstones in the gallbladder. Associated with rapid weight loss rather than the drug directly. Symptoms include sharp pain in the upper right abdomen after eating fatty foods. Requires medical attention.","clinicalRates":{"low":0.008,"medium":0.015,"high":0.026},"clinicalRatesNote":"A fixed published-literature dose-response reference (dated 2026-04-12), not derived from this corpus. The predictor uses it only as a fallback when the corpus has no eligible clinical rate points for this effect; otherwise the predictor uses the corpus's own weighted rate. The corpus's own pooled clinical estimate is published alongside — corpusClinical here, rateBase.clinical.pooledEstimate on the per-effect endpoint — and is null when the corpus has no eligible clinical rate points for the effect. Full per-source detail: rateBase.clinical via ?q=effect&id=<id>.","modifiers":{"femaleFactor":1.6,"ageFactor65plus":1.4,"giHistoryFactor":1.3,"diabetesFactor":1.2,"firstMonthFactor":0.5},"reportingFrequency":{"mentions":27,"distinctReports":185,"sharePct":14.6,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself — news-aggregator results are excluded, see platforms. Not an incidence rate; not comparable to clinicalRates."},"userReportedSeverity":"Users who develop gallstones typically describe it as sudden, intense pain in the upper right abdomen — often after a fatty meal. Some required surgery (cholecystectomy). More common in those losing weight rapidly.","onsetDays":"Typically months into treatment, correlates with significant weight loss","durationWeeks":"Requires medical intervention — does not resolve on its own","managementTip":"If you experience sudden sharp pain in the upper right abdomen, especially after eating, seek medical attention. Losing weight gradually (not too fast) reduces risk. Stay hydrated.","sources":[{"name":"STEP-1 Trial (Wilding et al., NEJM 2021)","type":"clinical","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2032183","weight":0.3},{"name":"FDA safety communication on GLP-1 and gallbladder events (2024)","type":"news","weight":0.3},{"name":"Reddit r/Ozempic gallbladder removal posts (2024-2026)","type":"user_report","weight":0.4}]},"dataPointCount":68,"rateBase":{"note":"Only externally citable, non-duplicated rates support an estimate. Shares of spontaneous adverse-event reports (FAERS) are reported separately — they are not incidence.","clinical":{"statedRates":4,"distinctSources":2,"pooledEstimate":{"ratePct":3.4,"ciLowPct":2,"ciHighPct":7,"statedRates":4,"distinctSources":2,"confidence":"low"},"sources":[{"name":"STEP-1 Trial (Wilding et al., NEJM 2021)","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2032183","rate":0.016,"sampleSize":500},{"name":"PubMed — Guts, Glucose, and Gallbladders: The Protective Role of GLP-1/GIP Receptor ","url":"https://pubmed.ncbi.nlm.nih.gov/41464784/","rate":0.035,"sampleSize":16026}],"excluded":{"no_rate":9},"usesPublishedFallback":false},"community":{"statedRates":0,"distinctSources":0,"excluded":{"no_rate":48,"self_referential":6,"synthetic_source":1},"usesPublishedFallback":true},"spontaneousReportShares":[]},"dataPointsBySource":{"clinical":13,"regulatory":0,"user_report":50,"news":5},"sampleDataPoints":[{"sourceName":"Reddit r/compoundedtirzepatide — Semaglutide","sourceType":"user_report","sourceUrl":"https://reddit.com/r/Semaglutide/comments/1sgeysm/semaglutide/","extractedRate":null,"extractedSeverity":"severe","extractedSampleSize":1,"extractionConfidence":"medium","scrapedAt":"2026-04-09T04:01:38.133Z"},{"sourceName":"Reddit r/compoundedtirzepatide — So happy","sourceType":"user_report","sourceUrl":"https://reddit.com/r/womenintech/comments/1sgely2/so_happy/","extractedRate":null,"extractedSeverity":null,"extractedSampleSize":null,"extractionConfidence":"low","scrapedAt":"2026-04-09T04:01:36.801Z"},{"sourceName":"Reddit r/compoundedtirzepatide — High calorie safe foods","sourceType":"user_report","sourceUrl":"https://reddit.com/r/gallbladders/comments/1sgejpv/high_calorie_safe_foods/","extractedRate":null,"extractedSeverity":"moderate","extractedSampleSize":null,"extractionConfidence":"high","scrapedAt":"2026-04-09T04:01:41.206Z"},{"sourceName":"Reddit r/compoundedtirzepatide — Anyone have a polyp cause symptoms?","sourceType":"user_report","sourceUrl":"https://reddit.com/r/gallbladders/comments/1sgdgho/anyone_have_a_polyp_cause_symptoms/","extractedRate":null,"extractedSeverity":null,"extractedSampleSize":null,"extractionConfidence":"high","scrapedAt":"2026-04-09T04:01:42.405Z"},{"sourceName":"Reddit r/compoundedtirzepatide — Real Face of Living Prophet Jesus Christ Kalki Kriva Dna Print","sourceType":"user_report","sourceUrl":"https://reddit.com/r/Christianity/comments/1sgc3kr/real_face_of_living_prophet_jesus_christ_kalki/","extractedRate":null,"extractedSeverity":"severe","extractedSampleSize":null,"extractionConfidence":"low","scrapedAt":"2026-04-09T04:01:44.992Z"}],"lastUpdated":"2026-08-26"}