{"effect":{"id":"pancreatitis","name":"Pancreatitis (rare)","severity":"severe","description":"Inflammation of the pancreas. RARE but SERIOUS. Symptoms: severe stomach pain radiating to the back, nausea, vomiting. Stop treatment immediately and seek medical help.","clinicalRates":{"low":0.005,"medium":0.008,"high":0.012},"clinicalRatesNote":"A fixed published-literature dose-response reference (dated 2026-04-12), not derived from this corpus. The predictor uses it only as a fallback when the corpus has no eligible clinical rate points for this effect; otherwise the predictor uses the corpus's own weighted rate. The corpus's own pooled clinical estimate is published alongside — corpusClinical here, rateBase.clinical.pooledEstimate on the per-effect endpoint — and is null when the corpus has no eligible clinical rate points for the effect. Full per-source detail: rateBase.clinical via ?q=effect&id=<id>.","modifiers":{"femaleFactor":1,"ageFactor65plus":1.5,"giHistoryFactor":3,"diabetesFactor":1.3,"firstMonthFactor":1.2},"reportingFrequency":{"mentions":10,"distinctReports":185,"sharePct":5.4,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself — news-aggregator results are excluded, see platforms. Not an incidence rate; not comparable to clinicalRates."},"userReportedSeverity":"Very rarely reported by users, but when it occurs it is described as extremely painful. Anyone who experienced it says: 'you will know immediately something is very wrong.'","onsetDays":"Can occur at any point during treatment","durationWeeks":"Requires immediate medical attention","managementTip":"If you experience severe stomach pain radiating to your back: STOP the medication immediately and go to the emergency room. Do not wait.","sources":[{"name":"Washington University comprehensive study (2025)","type":"clinical","url":"https://medicine.washu.edu/news/study-identifies-benefits-risks-linked-to-popular-weight-loss-drugs/","weight":0.3},{"name":"FDA adverse event reports (2024-2025)","type":"news","weight":0.3},{"name":"Patient advocacy forums reporting (2024-2026)","type":"user_report","weight":0.4}]},"dataPointCount":50,"rateBase":{"note":"Only externally citable, non-duplicated rates support an estimate. Shares of spontaneous adverse-event reports (FAERS) are reported separately — they are not incidence.","clinical":{"statedRates":3,"distinctSources":1,"pooledEstimate":{"ratePct":0.8,"ciLowPct":0,"ciHighPct":2,"statedRates":3,"distinctSources":1,"confidence":"very_low"},"sources":[{"name":"Washington University comprehensive study (2025)","url":"https://medicine.washu.edu/news/study-identifies-benefits-risks-linked-to-popular-weight-loss-drugs/","rate":0.008,"sampleSize":500}],"excluded":{"spontaneous_report_share":2,"no_rate":9},"usesPublishedFallback":false},"community":{"statedRates":0,"distinctSources":0,"excluded":{"self_referential":6,"synthetic_source":1,"no_rate":29},"usesPublishedFallback":true},"spontaneousReportShares":[{"source":"FDA FAERS — liraglutide — PANCREATITIS","url":"https://api.fda.gov/drug/event.json?search=patient.drug.openfda.generic_name:\"liraglutide\"","shareOfReports":0.054,"reports":2343},{"source":"FDA FAERS — exenatide — PANCREATITIS","url":"https://api.fda.gov/drug/event.json?search=patient.drug.openfda.generic_name:\"exenatide\"","shareOfReports":0.021,"reports":2011}]},"dataPointsBySource":{"clinical":12,"regulatory":2,"user_report":16,"news":20},"sampleDataPoints":[{"sourceName":"Washington University comprehensive study (2025)","sourceType":"clinical","sourceUrl":"https://medicine.washu.edu/news/study-identifies-benefits-risks-linked-to-popular-weight-loss-drugs/","extractedRate":0.005,"extractedSeverity":"severe","extractedSampleSize":200,"extractionConfidence":"high","scrapedAt":"2026-04-06T11:45:17.713Z"},{"sourceName":"Washington University comprehensive study (2025)","sourceType":"clinical","sourceUrl":"https://medicine.washu.edu/news/study-identifies-benefits-risks-linked-to-popular-weight-loss-drugs/","extractedRate":0.008,"extractedSeverity":"severe","extractedSampleSize":500,"extractionConfidence":"high","scrapedAt":"2026-04-06T11:45:17.713Z"},{"sourceName":"Washington University comprehensive study (2025)","sourceType":"clinical","sourceUrl":"https://medicine.washu.edu/news/study-identifies-benefits-risks-linked-to-popular-weight-loss-drugs/","extractedRate":0.012,"extractedSeverity":"severe","extractedSampleSize":300,"extractionConfidence":"high","scrapedAt":"2026-04-06T11:45:17.713Z"},{"sourceName":"FDA adverse event reports (2024-2025)","sourceType":"news","sourceUrl":"https://magistra.health/nl/science#pancreatitis","extractedRate":0.005,"extractedSeverity":"severe","extractedSampleSize":200,"extractionConfidence":"high","scrapedAt":"2026-04-06T11:45:17.713Z"},{"sourceName":"FDA adverse event reports (2024-2025)","sourceType":"news","sourceUrl":"https://magistra.health/nl/science#pancreatitis","extractedRate":0.008,"extractedSeverity":"severe","extractedSampleSize":500,"extractionConfidence":"high","scrapedAt":"2026-04-06T11:45:17.713Z"}],"lastUpdated":"2026-08-23"}