{"name":"Magistra GLP-1 Safety & Efficacy Database","version":"1.0","lastUpdated":"2026-09-14","totalEffectsTracked":15,"totalDataPoints":2197,"evidentiaryBase":{"corpusPoints":2347,"ratePoints":1110,"eligibleRates":887,"distinctSources":29,"sourceEntries":180,"seriousAeSourceEntries":10,"excluded":{"seed_unverified":150,"no_rate":1237,"spontaneous_report_share":62,"aggregator_result":11},"note":"Both corpusPoints and totalDataPoints are scoped to the 15 publicly-tracked effects (excluding kidney_issues/muscle_loss/weight_regain, extraction-only categories never displayed on the site); they differ only in that corpusPoints includes the April-2026 seed points retained for audit trail and totalDataPoints excludes them. Corrected 2026-09-11: until then totalDataPoints and dataPointsBySource were computed from an unscoped metadata blob, so this response published a corpus total 97 higher than the sum of its own dataPointsByEffect — totalDataPoints read 1,901 where the scoped figure is 1,804. Of the corpus, only ratePoints state a rate; after eligibility rules, eligibleRates are allowed to support a published estimate. distinctSources counts distinct STUDIES by source URL with its fragment stripped (a registry record or paper counts once however many effects it reports; re-keyed 2026-09-08 — until then this field counted one entry per source per effect, now exposed as sourceEntries). Per-effect breakdown: ?q=effect&id=<effect>, field rateBase, whose distinctSources is keyed the same way (re-keyed 2026-09-10 — it too counted one entry per source per effect until then, and still does under sourceEntries; the two differ only where one study posts more than one MedDRA preferred term for the same effect, e.g. SURMOUNT-1's Pancreatitis and Pancreatitis acute)."},"demographicCoverage":{"sexStated":231,"sexStatedCommunity":221,"ageRangeStated":185,"ageRangeStatedCommunity":167,"of":2197,"note":"Points carrying an extracted sex (not 'unspecified') or age range, over the same scoped set as totalDataPoints. Mostly community self-reports; the remainder are trial and news rows that state a sex or age band."},"dataPointsBySource":{"news":281,"user_report":722,"regulatory":62,"clinical":1132},"dataPointsByEffect":{"nausea":398,"diarrhea":227,"constipation":239,"reduced_appetite":164,"headache":132,"pancreatitis":62,"fatigue":96,"vomiting":247,"abdominal_pain":229,"acid_reflux":122,"gallstones":82,"hair_loss":37,"injection_site_reaction":51,"dizziness":71,"emotional_blunting":40},"lastScraped":"2026-09-14T09:52:08.426Z","drugsTracked":["semaglutide","tirzepatide","liraglutide","retatrutide","orforglipron","survodutide","dulaglutide","exenatide","lixisenatide"],"effectsTracked":[{"id":"nausea","name":"Nausea","severity":"mild","clinicalRateLow":0.15,"clinicalRateMedium":0.28,"clinicalRateHigh":0.4,"corpusClinical":{"ratePct":22.5,"ciLowPct":7,"ciHighPct":52,"statedRates":130,"distinctSources":27,"sourceEntries":27,"seriousAeSources":0,"rateKindNote":"","rateKindNoteNl":"","intervalBasis":"sampling_plus_between_study","intervalNote":"","intervalNoteNl":"","confidence":"very_high","sourceDiversity":"very_high"},"reportingFrequency":{"mentions":10,"distinctReports":26,"sharePct":38.5,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}},{"id":"diarrhea","name":"Diarrhoea","severity":"mild","clinicalRateLow":0.1,"clinicalRateMedium":0.18,"clinicalRateHigh":0.25,"corpusClinical":{"ratePct":16.6,"ciLowPct":3,"ciHighPct":58,"statedRates":81,"distinctSources":20,"sourceEntries":20,"seriousAeSources":0,"rateKindNote":"","rateKindNoteNl":"","intervalBasis":"sampling_plus_between_study","intervalNote":"","intervalNoteNl":"","confidence":"high","sourceDiversity":"high"},"reportingFrequency":{"mentions":9,"distinctReports":26,"sharePct":34.6,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}},{"id":"constipation","name":"Constipation","severity":"mild","clinicalRateLow":0.05,"clinicalRateMedium":0.12,"clinicalRateHigh":0.18,"corpusClinical":{"ratePct":11.6,"ciLowPct":2,"ciHighPct":41,"statedRates":120,"distinctSources":20,"sourceEntries":20,"seriousAeSources":0,"rateKindNote":"","rateKindNoteNl":"","intervalBasis":"sampling_plus_between_study","intervalNote":"","intervalNoteNl":"","confidence":"high","sourceDiversity":"high"},"reportingFrequency":{"mentions":7,"distinctReports":26,"sharePct":26.9,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}},{"id":"reduced_appetite","name":"Reduced appetite","severity":"mild","clinicalRateLow":0.08,"clinicalRateMedium":0.15,"clinicalRateHigh":0.22,"corpusClinical":{"ratePct":9.5,"ciLowPct":0,"ciHighPct":83,"statedRates":99,"distinctSources":19,"sourceEntries":19,"seriousAeSources":0,"rateKindNote":"","rateKindNoteNl":"","intervalBasis":"sampling_plus_between_study","intervalNote":"","intervalNoteNl":"","confidence":"high","sourceDiversity":"high"},"reportingFrequency":{"mentions":8,"distinctReports":26,"sharePct":30.8,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}},{"id":"headache","name":"Headache","severity":"mild","clinicalRateLow":0.08,"clinicalRateMedium":0.12,"clinicalRateHigh":0.14,"corpusClinical":{"ratePct":11,"ciLowPct":5,"ciHighPct":22,"statedRates":104,"distinctSources":13,"sourceEntries":13,"seriousAeSources":0,"rateKindNote":"","rateKindNoteNl":"","intervalBasis":"sampling_plus_between_study","intervalNote":"","intervalNoteNl":"","confidence":"high","sourceDiversity":"high"},"reportingFrequency":{"mentions":1,"distinctReports":26,"sharePct":3.8,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}},{"id":"pancreatitis","name":"Pancreatitis (rare)","severity":"severe","clinicalRateLow":0.002,"clinicalRateMedium":0.002,"clinicalRateHigh":0.002,"corpusClinical":{"ratePct":0.1,"ciLowPct":0,"ciHighPct":1,"statedRates":11,"distinctSources":3,"sourceEntries":5,"seriousAeSources":2,"rateKindNote":"2 of 3 sources are SERIOUS adverse-event rates from a trial registry's SAE table, which understate all-cause incidence","rateKindNoteNl":"2 van 3 bronnen zijn percentages voor ERNSTIGE bijwerkingen uit de SAE-tabel van een studieregister, wat de incidentie over alle ernstgraden onderschat","intervalBasis":"sampling_plus_between_study","intervalNote":"","intervalNoteNl":"","confidence":"low","sourceDiversity":"low"},"reportingFrequency":{"mentions":0,"distinctReports":26,"sharePct":0,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}},{"id":"fatigue","name":"Fatigue / Low energy","severity":"mild","clinicalRateLow":0.11,"clinicalRateMedium":0.11,"clinicalRateHigh":0.11,"corpusClinical":{"ratePct":6.5,"ciLowPct":2,"ciHighPct":22,"statedRates":25,"distinctSources":9,"sourceEntries":9,"seriousAeSources":0,"rateKindNote":"","rateKindNoteNl":"","intervalBasis":"sampling_plus_between_study","intervalNote":"","intervalNoteNl":"","confidence":"moderate","sourceDiversity":"moderate"},"reportingFrequency":{"mentions":3,"distinctReports":26,"sharePct":11.5,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}},{"id":"vomiting","name":"Vomiting","severity":"moderate","clinicalRateLow":0.03,"clinicalRateMedium":0.05,"clinicalRateHigh":0.08,"corpusClinical":{"ratePct":9.9,"ciLowPct":3,"ciHighPct":30,"statedRates":87,"distinctSources":23,"sourceEntries":23,"seriousAeSources":0,"rateKindNote":"","rateKindNoteNl":"","intervalBasis":"sampling_plus_between_study","intervalNote":"","intervalNoteNl":"","confidence":"high","sourceDiversity":"high"},"reportingFrequency":{"mentions":11,"distinctReports":26,"sharePct":42.3,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}},{"id":"abdominal_pain","name":"Abdominal pain","severity":"moderate","clinicalRateLow":0.03,"clinicalRateMedium":0.05,"clinicalRateHigh":0.07,"corpusClinical":{"ratePct":6.9,"ciLowPct":1,"ciHighPct":42,"statedRates":113,"distinctSources":16,"sourceEntries":16,"seriousAeSources":0,"rateKindNote":"","rateKindNoteNl":"","intervalBasis":"sampling_plus_between_study","intervalNote":"","intervalNoteNl":"","confidence":"high","sourceDiversity":"high"},"reportingFrequency":{"mentions":4,"distinctReports":26,"sharePct":15.4,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}},{"id":"acid_reflux","name":"Acid reflux (GERD)","severity":"mild","clinicalRateLow":0.03,"clinicalRateMedium":0.05,"clinicalRateHigh":0.08,"corpusClinical":{"ratePct":5.2,"ciLowPct":0,"ciHighPct":62,"statedRates":46,"distinctSources":12,"sourceEntries":12,"seriousAeSources":0,"rateKindNote":"","rateKindNoteNl":"","intervalBasis":"sampling_plus_between_study","intervalNote":"","intervalNoteNl":"","confidence":"high","sourceDiversity":"high"},"reportingFrequency":{"mentions":6,"distinctReports":26,"sharePct":23.1,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}},{"id":"gallstones","name":"Gallstones (cholelithiasis)","severity":"severe","clinicalRateLow":0.008,"clinicalRateMedium":0.015,"clinicalRateHigh":0.026,"corpusClinical":{"ratePct":1.7,"ciLowPct":1,"ciHighPct":5,"statedRates":17,"distinctSources":6,"sourceEntries":9,"seriousAeSources":3,"rateKindNote":"3 of 6 sources are SERIOUS adverse-event rates from a trial registry's SAE table, which understate all-cause incidence","rateKindNoteNl":"3 van 6 bronnen zijn percentages voor ERNSTIGE bijwerkingen uit de SAE-tabel van een studieregister, wat de incidentie over alle ernstgraden onderschat","intervalBasis":"sampling_plus_between_study","intervalNote":"","intervalNoteNl":"","confidence":"moderate","sourceDiversity":"moderate"},"reportingFrequency":{"mentions":3,"distinctReports":26,"sharePct":11.5,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}},{"id":"hair_loss","name":"Hair loss (thinning)","severity":"mild","clinicalRateLow":0.03,"clinicalRateMedium":0.03,"clinicalRateHigh":0.03,"corpusClinical":{"ratePct":5.3,"ciLowPct":4,"ciHighPct":7,"statedRates":5,"distinctSources":2,"sourceEntries":2,"seriousAeSources":0,"rateKindNote":"","rateKindNoteNl":"","intervalBasis":"sampling_plus_between_study","intervalNote":"","intervalNoteNl":"","confidence":"low","sourceDiversity":"low"},"reportingFrequency":{"mentions":1,"distinctReports":26,"sharePct":3.8,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}},{"id":"injection_site_reaction","name":"Injection site reaction","severity":"mild","clinicalRateLow":0.03,"clinicalRateMedium":0.04,"clinicalRateHigh":0.05,"corpusClinical":{"ratePct":4.5,"ciLowPct":0,"ciHighPct":53,"statedRates":4,"distinctSources":2,"sourceEntries":2,"seriousAeSources":0,"rateKindNote":"","rateKindNoteNl":"","intervalBasis":"sampling_plus_between_study","intervalNote":"","intervalNoteNl":"","confidence":"low","sourceDiversity":"low"},"reportingFrequency":{"mentions":6,"distinctReports":26,"sharePct":23.1,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}},{"id":"dizziness","name":"Dizziness","severity":"mild","clinicalRateLow":0.08,"clinicalRateMedium":0.08,"clinicalRateHigh":0.08,"corpusClinical":{"ratePct":6.5,"ciLowPct":4,"ciHighPct":11,"statedRates":45,"distinctSources":10,"sourceEntries":10,"seriousAeSources":0,"rateKindNote":"","rateKindNoteNl":"","intervalBasis":"sampling_plus_between_study","intervalNote":"","intervalNoteNl":"","confidence":"high","sourceDiversity":"high"},"reportingFrequency":{"mentions":2,"distinctReports":26,"sharePct":7.7,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}},{"id":"emotional_blunting","name":"Emotional blunting / Reduced pleasure","severity":"moderate","clinicalRateLow":null,"clinicalRateMedium":null,"clinicalRateHigh":null,"clinicalRatesWithdrawn":true,"corpusClinical":null,"reportingFrequency":{"mentions":0,"distinctReports":26,"sharePct":0,"platforms":["reddit.com","drugs.com"],"note":"Share of distinct community reports (one row per source URL) that mention this effect. Counts only reports hosted on the community platform itself, and — corrected 2026-08-29 — only Reddit posts from the GLP-1, weight-management and diabetes subreddits we collect from: the scraper's subreddit restriction was not holding, and 159 of the previous 185 reports were posts matched on a symptom word in unrelated communities (r/gallbladders, r/AskDocs, r/pregnant). News-aggregator results are excluded, see platforms. The remaining base is small and cannot currently grow (Reddit has blocked our collector since 2026-05-28), so read every share with its distinctReports denominator. Not an incidence rate; not comparable to clinicalRates."}}],"clinicalRatesNote":"A fixed reference table dated 2026-04-12, not derived from this corpus and carrying no per-effect citation of its own — see `sources` on ?q=effect&id=<id> for what was recorded behind each effect. It reaches published numbers two ways. (1) As the sole clinical base for an effect with no eligible corpus rate point — exactly the effects whose pooled corpus estimate is null (corpusClinical here, rateBase.clinical.pooledEstimate on the per-effect endpoint); the predictor marks these isFallback: true. (2) Since 2026-08-28, as a dose-tier rescale ratio applied to the corpus's OWN pooled rate wherever that tier's pooled clinical records are mostly dose-untagged; isFallback stays false in that case, and the predictor's clinical.basis states both endpoints and the dose-tag denominator while clinical.pooledPercentage carries the corpus rate before any adjustment. Full per-source detail: rateBase.clinical via ?q=effect&id=<id>. WITHDRAWN 2026-09-03 (decision literature-fallback-clinical-rate-2026-08-28, option c) for emotional_blunting only: this table had no rate-stating source at all for it, so its clinicalRate fields are null here and its predictor track carries `available: false` with no percentage — see clinicalRatesWithdrawn on ?q=effect&id=emotional_blunting. RE-SOURCED 2026-09-03 (same decision, option b) for fatigue only: its three tier values are one figure, 0.11, from the FDA Wegovy prescribing information revised 06/2026 (Table 3: fatigue incl. asthenia 11% on 2.4 mg, N=2,116, vs 5% placebo, N=1,261; URL in its sources) — the label reports no per-dose-tier rate, so no gradient is published for it, and it is a semaglutide figure applied at every dose tier regardless of molecule, as this whole table is. RE-SOURCED 2026-09-04 (decision pancreatitis-hairloss-dizziness-triple-derivation-2026-09-03) for hair_loss, dizziness and pancreatitis: their 2026-04-12 triples (1–3%, 2–5%, 0.5–1.2%) had no recorded derivation and their cited trial pages state no such figures; each is now one value at every tier from the same FDA Wegovy label — hair_loss 0.03 (Table 3: 3% on 2.4 mg, N=2,116, vs 1% placebo), dizziness 0.08 (Table 3: 8% vs 4%), and pancreatitis 0.002, which is NOT a proportion of patients like every other value in this table but the label's incidence RATE of 0.2 acute-pancreatitis cases per 100 patient-years of Wegovy exposure (4 adjudicated cases vs 1 on placebo, section 5) — read it with that unit. Figures served before 2026-09-04 for these three effects should not be cited.","confidenceNote":"`sourceDiversity` (formerly `confidence`, kept as a deprecated alias with the same value) measures SOURCE DIVERSITY, not precision: it is derived only from distinctSources (≤1 very_low, ≤3 low, ≤9 moderate, ≤24 high, ≥25 very_high) and is computed without reference to the confidence interval. It can read `moderate` on an estimate whose interval spans nearly the whole range — always read ciLowPct/ciHighPct alongside it, and treat a wide interval as the binding statement about how well we know the rate. The converse does NOT hold, and until 2026-09-11 nothing here said so: a NARROW interval is not evidence of a well-known rate. τ² (the between-study heterogeneity term) is 0 by construction when a single source entry contributes, so such an estimate publishes that one study's sampling interval and nothing else — read `intervalBasis` on every pooled block (`sampling_only_single_source` vs `sampling_plus_between_study`, with `intervalNote`/`intervalNoteNl` spelling it out) before reading a tight range as precision.","samplingNote":"Known upward bias, not yet corrected: registry rows collected before 2026-09-10 through the rotation path were capped at the five highest-percentage arm rows per trial, which selects on the rate being measured. 19 of the 25 trials with stored registry rows are affected; the six pinned pivotal trials (SURMOUNT-1, SELECT, STEP 1, STEP 2, SURPASS-CVOT, retatrutide phase 2) are not, because they emit every non-placebo arm. Pooled clinical estimates that draw on an affected trial therefore read HIGH by an amount we have not yet quantified per effect. The collector was fixed 2026-09-10; the stored rows await a re-collection. Method and per-trial measurements: §4 Limitations and correction-log item 25 of the published methodology, https://github.com/saurabhgoyal75/magistra-predictor/blob/main/preprint/magistra-methodology.md.","dataSources":[{"source":"ClinicalTrials.gov (API v2)","points":903,"lastSeen":"2026-09-14","stale":false},{"source":"Reddit (16 subreddits)","points":660,"lastSeen":"2026-05-28","stale":true},{"source":"Health news (Google News RSS)","points":279,"lastSeen":"2026-09-14","stale":false},{"source":"PubMed / PMC (NCBI E-utilities)","points":222,"lastSeen":"2026-09-14","stale":false},{"source":"FDA FAERS (openFDA API)","points":62,"lastSeen":"2026-08-13","stale":true},{"source":"Drugs.com patient reviews","points":62,"lastSeen":"2026-08-12","stale":true},{"source":"Journal & institutional pages","points":5,"lastSeen":"2026-04-12","stale":true},{"source":"medRxiv / bioRxiv preprints","points":4,"lastSeen":"2026-08-22","stale":false}],"dataSourcesNote":"Derived from the live corpus, scoped to the 15 publicly-tracked effects. `points` is how many data points that source has contributed; `stale: true` means no new point in 30+ days (the collector is blocked, rate-limited or retired).","trialsCited":["SURMOUNT-1 (NEJM 2022)","SELECT (NEJM 2023)"],"apiDocs":{"overview":"/api/data?q=overview","effectDetail":"/api/data?q=effect&id=nausea","countries":"/api/data/countries","bulkAccess":"https://magistra.health/en/data-api (purchased CSV export, full corpus with source URLs)"},"citation":"Magistra Health. GLP-1 Safety & Efficacy Database. magistra.health. Accessed 2026-09-14","license":"Free for research and journalism with attribution (Magistra, magistra.health); no redistribution of the dataset. Bulk export and commercial use via the research subscription.","licenseUrl":"https://magistra.health/en/data#licence","aggregateRatesTable":{"description":"The effectsTracked rate/CI/n/distinctSources figures above, as a standalone per-effect summary table.","license":"https://creativecommons.org/licenses/by/4.0/","csv":"https://magistra.health/data/glp1-aggregate-rates.csv","json":"https://magistra.health/data/glp1-aggregate-rates.json"},"contact":"saurabh@magistra.health"}