{
  "@context": "https://schema.org",
  "@type": "Dataset",
  "name": "Magistra GLP-1 Aggregate Pooled Side Effect Rates",
  "description": "Per-effect summary table only: pooled clinical rate estimate (with 95% CI, stated rates, distinct sources) and community reporting frequency (mentions, distinct reports) for each of the 15 tracked GLP-1 side effects. Computed from Magistra's underlying point-level corpus, which is NOT included here and remains under a separate attribution/no-redistribution licence (see licenseUrl). This summary table may be redistributed with attribution. Figures are pulled live from https://magistra.health/api/data?q=overview at build time — never hand-typed.",
  "version": "1.1",
  "asOf": "2026-09-06",
  "generatedAt": "2026-09-06T14:46:57.306Z",
  "license": "https://creativecommons.org/licenses/by/4.0/",
  "licenseNote": "This aggregate table (effect, pooled rate, CI, n, distinct sources) is CC BY 4.0 — free to redistribute with attribution (Magistra, magistra.health). The underlying point-level corpus is NOT covered by this licence; see https://magistra.health/en/data#licence.",
  "licenseUrl": "https://magistra.health/en/data#licence",
  "creator": {
    "@type": "Organization",
    "name": "Magistra",
    "url": "https://magistra.health"
  },
  "isBasedOn": "https://magistra.health/en/methodology",
  "distribution": [
    {
      "@type": "DataDownload",
      "encodingFormat": "text/csv",
      "contentUrl": "https://magistra.health/data/glp1-aggregate-rates.csv"
    }
  ],
  "citation": "Magistra Health. \"GLP-1 Aggregate Pooled Side Effect Rates.\" magistra.health/data/glp1-aggregate-rates.json. Accessed 2026-09-06.",
  "methodologyNote": "clinicalPooledRatePct/CI: weighted random-effects pooled rate across eligible clinical + regulatory rate points, one entry per distinct source (src/lib/side-effects-engine.ts::pooledClinicalEstimate, exposed live at /api/data?q=overview -> effectsTracked[].corpusClinical). Null when the corpus has zero eligible clinical rate points for that effect. communityReportingFrequencyPct: of N distinct community reports (corpus-wide, deduped by URL), the share mentioning this effect — NOT an incidence rate, see /en/methodology (src/lib/rate-base.ts::buildReportingFrequency).",
  "disclaimer": "Data, not medical advice. Reporting frequency is not incidence — do not compare it to the clinical rate as if the two measured the same thing.",
  "evidentiaryBase": {
    "corpusPoints": 1573,
    "ratePoints": 334,
    "eligibleRates": 93,
    "distinctSources": 59,
    "effectsTracked": 15,
    "communityDistinctReports": 26,
    "note": "corpusPoints includes the April-2026 seed points retained for audit trail (totalDataPoints excludes them). Of the corpus, only ratePoints state a rate; after eligibility rules, eligibleRates from distinctSources are allowed to support a published estimate, collapsed to one entry per source. Per-effect breakdown: ?q=effect&id=<effect>, field rateBase."
  },
  "effects": [
    {
      "effect": "nausea",
      "effectName": "Nausea",
      "severity": "mild",
      "clinicalPooledRatePct": 32,
      "clinicalCiLowPct": 9,
      "clinicalCiHighPct": 70,
      "clinicalStatedRates": 35,
      "clinicalDistinctSources": 24,
      "clinicalSourceDiversity": "high",
      "communityReportingFrequencyPct": 38.5,
      "communityMentions": 10,
      "communityTotalReports": 26
    },
    {
      "effect": "diarrhea",
      "effectName": "Diarrhoea",
      "severity": "mild",
      "clinicalPooledRatePct": 19.9,
      "clinicalCiLowPct": 3,
      "clinicalCiHighPct": 64,
      "clinicalStatedRates": 16,
      "clinicalDistinctSources": 10,
      "clinicalSourceDiversity": "high",
      "communityReportingFrequencyPct": 34.6,
      "communityMentions": 9,
      "communityTotalReports": 26
    },
    {
      "effect": "constipation",
      "effectName": "Constipation",
      "severity": "mild",
      "clinicalPooledRatePct": 28.2,
      "clinicalCiLowPct": 13,
      "clinicalCiHighPct": 51,
      "clinicalStatedRates": 10,
      "clinicalDistinctSources": 7,
      "clinicalSourceDiversity": "moderate",
      "communityReportingFrequencyPct": 26.9,
      "communityMentions": 7,
      "communityTotalReports": 26
    },
    {
      "effect": "reduced_appetite",
      "effectName": "Reduced appetite",
      "severity": "mild",
      "clinicalPooledRatePct": 20.9,
      "clinicalCiLowPct": 3,
      "clinicalCiHighPct": 72,
      "clinicalStatedRates": 10,
      "clinicalDistinctSources": 9,
      "clinicalSourceDiversity": "moderate",
      "communityReportingFrequencyPct": 30.8,
      "communityMentions": 8,
      "communityTotalReports": 26
    },
    {
      "effect": "headache",
      "effectName": "Headache",
      "severity": "mild",
      "clinicalPooledRatePct": 18.4,
      "clinicalCiLowPct": 14,
      "clinicalCiHighPct": 23,
      "clinicalStatedRates": 5,
      "clinicalDistinctSources": 4,
      "clinicalSourceDiversity": "moderate",
      "communityReportingFrequencyPct": 3.8,
      "communityMentions": 1,
      "communityTotalReports": 26
    },
    {
      "effect": "pancreatitis",
      "effectName": "Pancreatitis (rare)",
      "severity": "severe",
      "clinicalPooledRatePct": null,
      "clinicalCiLowPct": null,
      "clinicalCiHighPct": null,
      "clinicalStatedRates": 0,
      "clinicalDistinctSources": 0,
      "clinicalSourceDiversity": null,
      "communityReportingFrequencyPct": 0,
      "communityMentions": 0,
      "communityTotalReports": 26
    },
    {
      "effect": "fatigue",
      "effectName": "Fatigue / Low energy",
      "severity": "mild",
      "clinicalPooledRatePct": null,
      "clinicalCiLowPct": null,
      "clinicalCiHighPct": null,
      "clinicalStatedRates": 0,
      "clinicalDistinctSources": 0,
      "clinicalSourceDiversity": null,
      "communityReportingFrequencyPct": 11.5,
      "communityMentions": 3,
      "communityTotalReports": 26
    },
    {
      "effect": "vomiting",
      "effectName": "Vomiting",
      "severity": "moderate",
      "clinicalPooledRatePct": 8.1,
      "clinicalCiLowPct": 0,
      "clinicalCiHighPct": 94,
      "clinicalStatedRates": 10,
      "clinicalDistinctSources": 10,
      "clinicalSourceDiversity": "high",
      "communityReportingFrequencyPct": 42.3,
      "communityMentions": 11,
      "communityTotalReports": 26
    },
    {
      "effect": "abdominal_pain",
      "effectName": "Abdominal pain",
      "severity": "moderate",
      "clinicalPooledRatePct": 12.5,
      "clinicalCiLowPct": 4,
      "clinicalCiHighPct": 32,
      "clinicalStatedRates": 1,
      "clinicalDistinctSources": 1,
      "clinicalSourceDiversity": "very_low",
      "communityReportingFrequencyPct": 15.4,
      "communityMentions": 4,
      "communityTotalReports": 26
    },
    {
      "effect": "acid_reflux",
      "effectName": "Acid reflux (GERD)",
      "severity": "mild",
      "clinicalPooledRatePct": 33.3,
      "clinicalCiLowPct": 23,
      "clinicalCiHighPct": 45,
      "clinicalStatedRates": 1,
      "clinicalDistinctSources": 1,
      "clinicalSourceDiversity": "very_low",
      "communityReportingFrequencyPct": 23.1,
      "communityMentions": 6,
      "communityTotalReports": 26
    },
    {
      "effect": "gallstones",
      "effectName": "Gallstones (cholelithiasis)",
      "severity": "severe",
      "clinicalPooledRatePct": 3.5,
      "clinicalCiLowPct": 3,
      "clinicalCiHighPct": 4,
      "clinicalStatedRates": 1,
      "clinicalDistinctSources": 1,
      "clinicalSourceDiversity": "very_low",
      "communityReportingFrequencyPct": 11.5,
      "communityMentions": 3,
      "communityTotalReports": 26
    },
    {
      "effect": "hair_loss",
      "effectName": "Hair loss (thinning)",
      "severity": "mild",
      "clinicalPooledRatePct": null,
      "clinicalCiLowPct": null,
      "clinicalCiHighPct": null,
      "clinicalStatedRates": 0,
      "clinicalDistinctSources": 0,
      "clinicalSourceDiversity": null,
      "communityReportingFrequencyPct": 3.8,
      "communityMentions": 1,
      "communityTotalReports": 26
    },
    {
      "effect": "injection_site_reaction",
      "effectName": "Injection site reaction",
      "severity": "mild",
      "clinicalPooledRatePct": 14.3,
      "clinicalCiLowPct": 2,
      "clinicalCiHighPct": 58,
      "clinicalStatedRates": 1,
      "clinicalDistinctSources": 1,
      "clinicalSourceDiversity": "very_low",
      "communityReportingFrequencyPct": 23.1,
      "communityMentions": 6,
      "communityTotalReports": 26
    },
    {
      "effect": "dizziness",
      "effectName": "Dizziness",
      "severity": "mild",
      "clinicalPooledRatePct": null,
      "clinicalCiLowPct": null,
      "clinicalCiHighPct": null,
      "clinicalStatedRates": 0,
      "clinicalDistinctSources": 0,
      "clinicalSourceDiversity": null,
      "communityReportingFrequencyPct": 7.7,
      "communityMentions": 2,
      "communityTotalReports": 26
    },
    {
      "effect": "emotional_blunting",
      "effectName": "Emotional blunting / Reduced pleasure",
      "severity": "moderate",
      "clinicalPooledRatePct": null,
      "clinicalCiLowPct": null,
      "clinicalCiHighPct": null,
      "clinicalStatedRates": 0,
      "clinicalDistinctSources": 0,
      "clinicalSourceDiversity": null,
      "communityReportingFrequencyPct": 0,
      "communityMentions": 0,
      "communityTotalReports": 26
    }
  ]
}